The identification of small molecule protein ligands remains a key hurdle for the validation and translation of novel targets pivotal to the successful development of new medicines. However, the costly resources to deliver an effective compound screening campaign and the contractual commitment to the screening organisations, limit the development of drug discovery projects for biomedical researchers.
To address this capability gap we have established a small-molecule discovery workflow based on the DNA-encoded library (DEL) chemistry technology that will provide cost-free and commitment-free access to high-throughput screening for academic research groups.
Our libraries cover a diverse chemical space by up to 6 million compounds that have been by selections against carbonic anhydrase CA IX, IRE1 and [...].
